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Genetics could influence whether Ebola will kill: study

เผยแพร่:   โดย: MGR Online

At a high-security, state-of-the-art biocontainment laboratory in Hamilton, Montana, scientists infected mice with a mouse form of the same species of the Ebola virus that is sweeping West Africa.
The Ebola virus is often deadly, but not always, and a study on mice Thursday suggested that genetics may play a role in the severity of the illness.

AFP

About 19 percent of the mice lost weight initially but then regained it in two weeks and made a full recovery.
Scientists said the variability in outcomes resembled what has been seen in the human epidemic sweeping West Africa this year, killing more than 4,900 people and infecting more than 13,000.
Those that died showed more activity in genes that promoted blood vessel inflammation and cell death, leading to more serious illness.
Those that survived tended to show more activity in genes responsible for blood vessel repair and making infection-fighting white blood cells.
Specialized types of liver cells might have also helped stop the virus from reproducing, the study said.
Similar observations about the link between genes and outcomes have been made in many different viruses, so the finding should not come as a surprise in Ebola, said Andrew Easton, professor of virology at the University of Warwick.
The study also did not account for environmental factors that experts say can affect whether a person lives or dies from Ebola, including the quality of care, their age and how healthy they are when they first become infected.
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